Does the success of hyperthermia depend on the heating-method?

Background: Oncothermia has a quarter-century history [1]. It was started by typical invasive solution (ECT, electro-cancer-therapy) and tried also invasive interstitial technology; even systemic heating was also in the production range. However, the non-invasive loco-regional (EHY2000 series) and the multilocal (EHY3000 series) products, together with the intraluminar application (EHY1000 series) became popular among professionals. Why has Oncotherm tried so many forms of synergy of electric and thermal effects? Because it had historically the same frustration as hyperthermia had in general with the start of A d'Arsonval through W. Coley or HI. Robins to H. LeVeen. My objective is to discuss the challenges and show the possible solutions of present status of oncological hyperthermia.